Life sciences firm announces new test to help combat COVID-19

Alastair Smith CEO Avacta Group

Wetherby-based Avacta Group will launch a new laboratory test for the SARS-CoV-2 spike protein to support global research efforts into the coronavirus that causes COVID-19.

Enzyme linked immunosorbent assays (“ELISAs”) are common research tools used to detect and quantify a target of interest in a wide range of samples.

Using the same Affimer reagents that are incorporated into its rapid coronavirus saliva test being developed with Cytiva, Avacta says it has devised a high performance ELISA laboratory test to detect the SARS-CoV-2 virus.

Avacta will make the ELISA test available as a kit so researchers globally can use it in their own laboratories to support research into the coronavirus.

The Affimer-based ELISA test is capable of detecting the coronavirus spike protein in laboratory samples down to very low concentrations.

An evaluation of the ELISA carried out with The Liverpool School of Tropical Medicine using SARS-CoV-2 virus samples shows it can detect as little as a few thousand virus infectious units per millilitre of sample.

This is typical of the levels found in infectious COVID-19 patients’ saliva whether they are symptomatic or not.

The Affimer-based ELISA test is also highly specific to the SARS-CoV-2 virus with no cross-reactivity against other closely related coronavirus spike proteins.

Dr Alastair Smith, chief executive of Avacta Group, said: “Avacta remains focused on the much larger opportunity of the saliva-based coronavirus antigen rapid test that we are developing with Cytiva and which is now in the process of technology transfer to our manufacturing partners.

“The excellent analytical performance of the ELISA test is very encouraging with regards to the anticipated clinical performance of the rapid test and I look forward to starting the clinical validation with the first pilot batch of rapid tests as soon as possible.”

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